公告专利授权推介：
（1）专利名称：2-alkoxy benzene formyl arylamine compound and pharmaceutical use there of
公告号：CA2958927C
发明人：叶德泳; 李亚莉; 周璐; 王鹏辉; 楚勇; 龚昊隽; 黄祺; 陈彦; 张志宽
摘要：Disclosed are a 2-alkyloxy benzene formyl arylamine compound as represented by formula I, and use of a pharmaceutically acceptable salt thereof or a pharmaceutical composition utilizing the compound as an effective active ingredient in a drug for preventing and treating diseases caused by an abnormal increase in sphingomyelin levels; wherein, R, X, Y, Z and G are as defined in the specification, and the diseases comprise metabolic syndromes such as atherosclerosis (AS), fatty liver, obesity and type II diabetes mellitus.
（2）专利名称：Method and system for accelerating score-based generative models with preconditioned diffusion sampling
公告号：US11755888B1
发明人：Li Zhang; Hengyuan Ma; Xiatian Zhu; Jianfeng Feng
摘要：A method for accelerating score-based generative models (SGM) is provided, including setting a frequency mask (R) and a space mask (A) and a target sampling iteration number (T); sampling an initial sample (x0); conducting iteration comprising steps as follows : sampling a noise term; applying a preconditioned diffusion sampling (PDS) operator (M) to the noise term and thus generate a preconditioned noise term; calculating a drift term; applying the transpose of the PDS operator (MT) and then applying the PDS operator (M) to the drift term, and thus generate a preconditioned drift term; diffusing the sample of each iteration (xt); and outputting the result.
（3）专利名称：Large current-readout ferroelectric single-crystal thin film memory as well as method of preparing the same and method of operating the same
公告号：USRE049620E
发明人：江安全; 耿文平
摘要：Disclosed is a non-destructive large current-readout ferroelectric single-crystal thin film memory as well as a method of preparing the ferroelectric memory and a method of operating the ferroelectric memory. The large current-readout ferroelectric single-crystal thin film memory comprises a ferroelectric storage layer, which is a ferroelectric single-crystal storage layer. The non-destructive readout ferroelectric memory has a greatly increased read current in an on-state, and moreover, the data retention performance and data endurance performance are improved.
公布专利申请推介：
（1）专利名称：Use of ITPRIPL1 Modulators in Modulating the Immune Response or Manufacturing Antitumor Drugs
申请号：KR1020237018029A
发明人：许杰; 邓守言; 宋腾; 王一婷; 王运刚; 王焕彬; 池浩
摘要：The present invention provides the use of ITPRIPL1 regulator in the preparation of medicine for regulating immune reaction or resisting tumor. The said regulator is used in increasing or decreasing the expression or function of ITPRIPL1 gene or protein in body. Pharmaceutical compositions, including modulators for such uses, are also provided. Also provided are antibodies that recognize and bind isolated ITPRIPL1 recombinant proteins and ITPRIPL1.
（2）专利名称：In vivo multidimensional stress-strain testing device for plantar soft tissues
申请号：NL2034960A
发明人：黄然; 吴龙燕; 朱钧; 马昕
摘要：The present invention relates to the technical field of human detection and provides an in vivo multidimensional stress-strain testing device for plantar soft tissues, comprising a test bench provided with a testing area corresponding to a sole, a radial stress-strain testing unit configured to load and measure periodic vertical tensile pressure on plantar soft tissues, a shear stress-strain testing unit for loading and measuring cyclic transverse shear forces on plantar soft tissues, a torsion stress-strain testing unit for loading and measuring cyclic torsion on plantar soft tissues, an X-Y axis translation mechanism used to translate three stress-strain testing units horizontally, and lifting mechanisms used to realize vertical rise and fall of the three stress-strain testing units. The testing device of the present invention can realize force-displacement dynamic characteristic testing of positive pull pressure, shear force and torsional force of plantar soft tissues
（3）专利名称：Method for preparing a key intermediate for the synthesis of statins
申请号：US202117488276A
发明人：陈芬儿; 刘敏杰; 程荡; 黄则度; 陶媛; 王佳琦
摘要：Disclosed herein relates to organic synthesis, and more particularly to a method for preparing a key intermediate for the synthesis of statins. The key intermediate is 2-[(4R, 6S)-6-[(benzo[d]thiazol-2-ylthio)methyl]-2, 2-di substituted-1, 3-dioxan-4-yl] acetate of formula (I) : where R1 is a C1-C8 alkyl group, a C3-C8 cycloalkyl group, a monosubstituted or polysubstituted aryl group, or monosubstituted or polysubstituted aralkyl group; R2 is hydrogen, or monosubstituted or polysubstituted C1-C3 alkyl group, or halogen; and R3 and R4 are each independently a C1-C5 alkyl group, a C3-C7 cycloalkyl group, a C3-C7 cycloalkenyl group, a C1-C3 alkoxy group, a C6-C10 aryl group, or C7-C12 aralkyl group. In the method, a halomethyl compound and a thiol reagent are subjected to nucleophilic substitution in an organic solvent to synthesize a thioether, which then undergoes ketal exchange reaction with a carbonyl compound (V) in the presence of an organic acid to obtain a target product.
（4）专利名称：Metrology method and system for critical dimensions based on dispersion relation in momentum space
申请号：US202017927974A
发明人：李同宇; 石磊; 陈昂; 卢国鹏; 殷海玮; 资剑
摘要：Embodiments of the present disclosure relate to a metrology method and system for critical dimensions based on a dispersion relation in momentum space. The method comprises : establishing, in accordance with parameters of incident light and a modeled geometric topography of the target to be measured, a simulation dataset associated with a dispersion curve of the target to be measured in momentum space; training a neural-network-based prediction model based on the simulation dataset; obtaining, based on an actual measurement of the target to be measured by incident light, a dispersion relation pattern of the target to be measured in momentum space, wherein the dispersion relation pattern at least indicates a dispersion curve associated with the critical dimensions of the target to be measured; extracting, based on the dispersion relation pattern, features related to the dispersion curve from the dispersion relation pattern via the trained prediction model, to determine an estimated value associated with at least one critical dimension of the target to be measured. According to the method disclosed herein, at least one critical dimension is measured in a more efficient, economical and accurate way.
（5）专利名称：Magnetically induced torque measurement device and method based on torsional spring method
申请号：US202318109540A
发明人：尹勇; 邬小玫; 马迪蓉
摘要：The invention relates to the field of detection of implantable medical devices, particularly to magnetically induced torque measurement devices and method of implants in magnetic resonance imaging systems. The measurement device includes transmission shafts, gear sets, a knob, an indicator, a detachable torsion spring set, a loading tray, a protractor, and an MRI-compatible camera. The measurement device changes its measurement range by replacing the detachable torsion spring set, adjusts a height of the loading tray by a lifting platform, amplifies a rotation angle of the knob by the gear sets, and records deflection angles of the loading tray by the MRI-compatible camera. The measurement device provides the detachable torsion spring set, which is suitable for measuring most samples; and provides a height-adjustable loading tray, which can be applied to MR systems with different center heights.
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