概   况

2023年04月01日至06月30日期间，以复旦大学和以复旦大学相关的法人单位为权利人的专利共公布公告1353件（表1）。其中发明专利公布733件，发明专利授权公告321件，实用新型专利授权公告299件，详见附录一。

由图1专利类型可知发明专利占78%，共1054件，实用新型专利299件。

图1 专利类型分析（2023.04.01-2023.06.30）

专利公开国家/地区情况如图2所示，其中，中国专利1294件；PCT（WO）国际专利申请27件；国外专利32件，涉及7个国家/地区受理局，包括美国专利19件，欧洲（EPO）专利5件，日本专利2件，韩国专利2件，南非专利2件，澳大利亚专利1件，卢森堡专利1件。

图2 专利公开国家/地区分布（2023.04.01-2023.06.30）

院系分布

本期新公布公告专利主要集中在各理工科院系及附属医院（图3）。其中专利数量排名前五的院系为：中山医院（320件）、信息学院（133件）、计算机学院（98件）、微电子学院（82件）、华山医院（71件）。

图3 二级机构专利数量（2023.04.01-2023.06.30）

专利权人合作关系

复旦大学与合作单位共同申请或授权的专利133件，合作专利占比9.8%（图4）。主要合作单位包括：复旦大学义乌研究院（14）、珠海复旦创新研究院（8）、上海集成电路制造创新中心有限公司（7）、华为技术有限公司（6）、湖北江城实验室（5）、道生天合材料科技(上海)股份有限公司（3）、上海交通大学（3）、上海新氦类脑智能科技有限公司（3）、深圳华大基因股份有限公司（3）、司法鉴定科学研究院（3）、武汉永鼎光通科技有限公司（3）、中国科学院分子细胞科学卓越创新中心（3）、重庆长安汽车股份有限公司（3）等。节点大小代表专利件数，连线代表合作频次，连线越粗说明机构间合作越多。

图4 复旦大学专利合作情况（2023.04.01-2023.06.30）

注：数字代表两个专利权人之间合作的专利数量

发明人团队情况

1054件发明专利中，发明人团队情况如图5所示，主要的发明人团队分别是微电子学院张卫团队（30件），中山医院葛均波团队（23件），微电子学院史传进团队（12件），化学系孔彪团队（12件），信息科学于工程学院余建军团队（11件），信息科学与工程学院郑立荣团队（11件），化学系陈芬儿团队（10件），计算机科学技术学院卢暾团队（9件），中山医院周平红团队（9件）。节点大小代表专利件数，节点之间的连线代表发明人之间的合作关系（选择显示合作专利数排名前10名，合作次数排名前5名）。

图5 主要发明人团队（2023.04.01-2023.06.30）

研究领域分布

2023年04月至06月，复旦大学公布公告专利的研究领域主要集中在IPC分类中的A部、G部、C部和H部（图6）

图6 研究领域分布 （2023.04.01-2023.06.30）

其中，专利数量较多的组别集中在A61大类（584件，医学或兽医学；卫生学）和G06大类（317件，计算；推算；计数）。

进一步根据主IPC分类号的大组划分，如图7所示，排名在前5位的大组包括：（1）G06N3（138件），基于生物学模型的计算机装置。（2）A61K31（100件），含有机有效成分的医药配制品。（3）C12N15（90件），突变或遗传工程；遗传工程涉及的DNA或RNA，载体（如质粒）或其分离、制备或纯化；所使用的宿主。（4）C12Q1（86件） 包含酶、核酸或微生物的测定或检验方法；其组合物；这种组合物的制备方法。（5）G06V10（81件），图像或视频识别或理解的装置。

图7 主要的IPC组（2023.04.01-2023.06.30）

按照世界知识产权组织（WIPO）给出的35个技术领域划分，如图8所示，复旦大学2023年04月到06月期间公布公告的专利技术领域主要分布在医疗技术（407件）、计算机技术（288件）以及制药（177件）等领域。

图8 技术领域分布（2023.04.01-2023.06.30）

高价值专利

利用Innography专利数据库对2023年04月至06月期间复旦大学公布公告的专利，筛选出前25件高强度专利1，参见表2。

表2 复旦大学2023年第二季度高强度专利

1 Innography专利强度采纳了诸多价值参数包括专利引用次数和被引次数、专利权利要求数量、专利从申请到公开的时间长度、权利同族专利数量、专利的诉讼数据等。

发生转移许可的专利

1353件专利中有11件专利发生专利申请权的转移、5件专利实施许可（表3）2。

表3 复旦大学2023年第二季度专利转移与许可

2 本报告涉及的专利转化数据来自国家知识产权局网站的中国专利公布公告。

公告公布专利精选推介

公告专利授权推介：

（1）专利名称：Modeling method and apparatus for diagnosing ophthalmic disease based on artificial intelligence, and storage medium

公告号：US11636340B2

发明人：刘小青；洪佳旭；倪勇；李双双；王丽丽；何微；郭又文；刘宇轩；刘勇；王威；许睿琦；程静怡；田丽佳；陈文彬；徐讯

摘要：The present disclosure proposes a modeling method and apparatus for diagnosing an ophthalmic disease based on artificial intelligence, and a storage medium. The modeling method includes: establishing a data collection of ophthalmic images and a data collection of non-image ophthalmic disease diagnosis questionnaires; training a first neural network model by employing the data collection of the ophthalmic images to obtain a first classification model; training a second classification model by employing the data collection of non-image ophthalmic disease diagnosis questionnaires; and merging the first classification model and the second classification model to obtain a target classification network model, in which, a test result outputted by the target classification network model is used as a diagnosis result of the ophthalmic disease.

（2）专利名称：2-2-alkyloxy benzene formyl arylamine compound and pharmaceutical use thereof

公告号：KR102544838B1

发明人：叶德泳；李亚莉；周璐；王鹏辉；楚勇；龚昊隽；黄祺；陈彦；张志宽

摘要：The present invention relates to a 2-alkoxy benzene formyl arylamine compound represented by the formula (I) wherein R, G, X, Y and Z are in accordance with the detailed description of the invention. The above-mentioned compounds can inhibit the activity of sphingomyelin synthase (SMS) and can be used for the treatment of diseases due to an increase in sphingomyelin level or more. The present invention also encompasses the use of a compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising the compound as an active active ingredient in a medicament for the prevention and treatment of diseases due to an increase in sphingomyelin level or higher. Diseases caused by elevated levels of sphingomyelin above include metabolic syndrome such as atherosclerosis, fatty liver, obesity, and type II diabetes.

（3）专利名称：Logic computing

公告号：US11647679B2

发明人：肖江；余伟超；兰金

摘要：A computing device including a logic track including two logic-track magnetic domains separated by a logic-track domain wall, an input track arranged crossing the logic track at a first position of the logic track, and an output track arranged crossing the logic track at a second position of the logic track near the logic-track domain wall. The input track includes at least one input-track magnetic domain, and each of the at least one input-track magnetic domain includes at least one input-track storage unit configured to store binary 0 or 1. The output track includes at least one output-track magnetic domain, and each of the at least one output-track magnetic domain includes at least one output-track storage unit configured to store binary 0 or 1.

（4）专利名称：Establishment and application of human immortalized B lymphocyte cell line group

公告号：US11643637B2

发明人：石乐明；郑媛婷；侯湾湾；李斌；陈兴栋；郁颖；王久存；金力

摘要：The present application provides a group of human immortalized B lymphocyte cell lines and use thereof, and specifically provides a combination of four closely related immortalized lymphocyte cell lines. The combination can be used as a reference substances for measuring the performance of a detection platform. When the four closely related immortalized lymphocyte cell lines are used as reference substances for epigenome, transcriptome, proteome, and metabolome, an intrinsic magnitude difference gradient can be formed to evaluate the sensitivity of histological detection.

（5）专利名称：Method for preparing 3-chloro-4-oxopentyl acetate using fully continuous-flow micro-reaction system

公告号：US11618727B2

发明人：陈芬儿；姜梅芬；刘敏杰；程荡；俞超；黄华山

摘要：This disclosure relates to organic synthesis, and more particularly to a method for preparing 3-chloro-4-oxopentyl acetate using a fully continuous-flow micro-reaction system. In this method, chlorine and an acetylbutyrolactone-containing liquid are simultaneously transported to a first micro-channel reactor for continuous chlorination to obtain α-acetyl-α-chloro-γ-butyrolactone. The reaction mixture is simultaneously transported to a micro-mixer and a second micro-channel reactor together with a mixed solution of glacial acetic acid, hydrochloric acid and water, and the continuous acylation is carried out to obtain 3-chloro-4-oxopentyl acetate. After quenched with a quenching agent, the reaction mixture was subjected to extraction and separation to obtain the 3-chloro-4-oxopentyl acetate.

（6）专利名称：Use of Wnt inhibitor Wnt-C59 in the preparation of a drug for the treatment of dilated cardiomyopathy by SCN5A mutation

公告号：JP7297146B2

发明人：葛均波；孙爱军；胡静静；杨坤

摘要：The invention relates to the technical field of biological medicines, in particular to application of a Wnt inhibitor Wnt-C59 in preparing a medicine for treating dilated cardiomyopathy caused by SCN5A mutation. The invention provides a method for improving the heart function prognosis of an SCN5A gene mutation dilated cardiomyopathy patient by using SCN5A genotype detection as an entry point and inhibiting Wnt/beta-Catenin channel abnormal activation caused by SCN5A gene mutation by using a Wnt channel specific inhibitor Wnt-C59 for the first time. Experiments detect the treatment effect of Wnt-C59 on dilated cardiomyopathy by constructing a model of dilated cardiomyopathy caused by aging and adriamycin, and indexes such as cardiac function change, activation of related signal molecules and the like, and provide a theoretical basis for the application of Wnt-C59 in clinical treatment of dilated cardiomyopathy. The invention provides a new treatment method for dilated cardiomyopathy caused by SCN5A mutation, brings eosin for the patients, and has good application prospect.

公布专利申请推介：

（1）专利名称：Tissue factor-targeted antibody-drug conjugate

公开号：US20230138930A1

发明人：余科；沈竞康；孟韬；马兰萍；张学赛；李晴柔

摘要：A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

（2）专利名称：Compounds for Prevention or Treatment of Lipid-Metabolism Related Disease

公开号：JP2023523051A

发明人：鲁伯埙；付玉华；丁澦

摘要：The present invention relates to the field of biomedicine, and specifically relates to an LC3 binding portion-lipid droplet binding portion-conjugate formed by means of covalently linking a structure capable of binding LC3 and a structure capable of binding lipid droplets, and a pharmaceutically acceptable salt, stereoisomer, solvate, polymorph, tautomer, isotope compound, metabolite or prodrug thereof, and the use thereof in the preparation of drugs for preventing or treating lipid metabolism-related diseases.

（3）专利名称：Broad-Spectrum Polypeptide Against Enterovirus and Application Thereof

公开号：US20230192769A1

发明人：周溪；陆路；方媛；秦成峰；姜世勃；邱洋；刘泽众

摘要：Provided are a series of polypeptides with antiviral activity. The present invention provides a new strategy for preventing and controlling Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses and provides a new theoretical basis for accelerating the research and development of a polypeptide small molecule drug against Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses.

（4）专利名称：Three-dimensional capacitor-inductor based on high functional density through silicon via structure and preparation method thereof

公开号：US20230115796A1

发明人：张卫；刘子玉；陈琳；孙清清

摘要：The invention pertains to the technical field of semiconductor devices, and specifically relates to a three-dimensional capacitor-inductor based on a high-functional-density through silicon via structure and a manufacturing method. The three-dimensional capacitor-inductor of the present invention includes : a substrate formed with a through silicon via; a three-dimensional capacitor, formed on a sidewall of the through silicon via, and sequentially including a first metal layer, a second insulating layer, and a second metal layer; and a three-dimensional inductor, composed of center-filled metal of the through silicon via and planar thick metal rewiring, wherein a first insulating layer is provided between the sidewall of the through silicon via and the three-dimensional capacitor, and a third insulating layer is provided between the three-dimensional capacitor and the three-dimensional inductor. The invention can effectively increase the values of capacitance and inductance in an integrated system, and at the same time can integrate capacitors and inductors near the chip in three-dimensional integration, and can also improve the functional density of through silicon via in three-dimensional integration and increase the utilization rate of silicon in system integration. Compared with discrete capacitors and inductors on other organic substrates, the integration can be greatly improved.

（5）专利名称：Composition of drug and wild-type cell-penetrating peptide derivative

公开号：EP4197558A1

发明人：魏刚；江宽；李德晃；王雁峰

摘要：The present invention belongs to the field of pharmaceutical formulations, and relates to a composition comprising a derivative of a wild-type cell-penetrating peptide penetratin and a drug having positive charge under physiological pH conditions. The derivative of the wild-type cell-penetrating peptide penetratin is a lipophilic derivative designed by using the wild-type cell-penetrating peptide penetratin, and the molecule is positively charged as a whole under physiological pH conditions. Said composition of the present invention, as an ocular drug delivery system, can enable a drug positively charged under physiological pH conditions to be absorbed to the posterior segment of the eye by means of eye dropping, thereby providing a new route for achieving ocular delivery of a drug positively charged under physiological pH conditions.

复旦大学知识产权信息服务中心联系方式：

联系人（图书馆）：徐老师  周老师

地  点：复旦大学文科图书馆 208室

咨询电话：021-55664282   

Email：zhouyi88@fudan.edu.cn

联系人（科研院）：肖老师  仲老师

地  点：复旦大学综合楼401-6

咨询电话：021-65643778/65642664    

Email：fdzy@fudan.edu.cn  

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编辑：吴玉莲

审核：徐轩

文章来源：复旦大学知识产权信息服务中心